NAD+ SubQ

The molecule at the center of cellular aging.

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell and is essential for two of the most fundamental biological processes: energy production and DNA repair. It is the primary substrate for sirtuins — the proteins responsible for regulating cellular aging, inflammation, and metabolic health — and for PARP enzymes, which repair damaged DNA.

The problem is that NAD+ levels decline dramatically with age. By middle age, most people have roughly half the NAD+ they had in their twenties. This decline is associated with reduced mitochondrial function, impaired DNA repair, increased inflammation, and the progressive cellular dysfunction that underlies aging and age-related disease.

Subcutaneous NAD+ injection delivers the molecule directly into the tissue beneath the skin, where it is absorbed steadily into the bloodstream. This route is gentler than IV infusion and well-suited for regular maintenance dosing — making it an ideal format for ongoing longevity and performance protocols. At HydraSpa, NAD+ SubQ is also available as part of our Home Vitamin Shot Program for clients who want to self-administer at home under clinical supervision.

Active ingredients

NAD+ (Nicotinamide Adenine Dinucleotide)

Essential coenzyme for mitochondrial energy production (ATP synthesis), sirtuin activation (longevity proteins), PARP-mediated DNA repair, and regulation of circadian rhythm and metabolic health.

What it may support

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Supports cellular energy production and mitochondrial function

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Activates sirtuins — proteins associated with longevity and healthy aging

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Supports DNA repair mechanisms

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Improves mental clarity, focus, and cognitive performance

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Enhances physical energy and reduces fatigue

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Supports metabolism and healthy weight management

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May reduce inflammation and oxidative stress

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Supports neurological health and neuroprotection

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Improves recovery from exercise and physical stress

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Supports circadian rhythm regulation and sleep quality

Individual results vary. These statements have not been evaluated by the FDA. Vitamin injections are not intended to diagnose, treat, cure, or prevent any disease.

How often should you get a NAD+ shot?

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Longevity and anti-aging protocol: 2–3 times per week initially, then weekly for maintenance

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Cognitive performance and mental clarity: weekly

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Athletic recovery and performance: 2–3 times per week during training

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General wellness maintenance: weekly to bi-weekly

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Home Vitamin Shot Program: self-administered SubQ on a schedule set by our clinical team

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NAD+ is most effective as a consistent, ongoing protocol — single doses produce limited results

Who is a good candidate?

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Adults over 40 seeking to support healthy aging and longevity

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Individuals experiencing cognitive decline, brain fog, or reduced mental sharpness

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Athletes and high-performance individuals seeking enhanced recovery and endurance

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People with chronic fatigue or mitochondrial dysfunction

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Those with neurodegenerative concerns or family history of cognitive decline

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Individuals recovering from addiction (NAD+ has been studied in addiction recovery protocols)

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Anyone interested in longevity medicine and cellular health optimization

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People seeking to enhance the effects of other wellness therapies

Common questions

What is the difference between NAD+ SubQ and NAD+ IV infusion?

IV NAD+ infusion delivers a higher dose directly into the bloodstream and is typically used for intensive protocols — addiction recovery, acute cognitive support, or rapid replenishment. SubQ injection delivers a lower, steady dose absorbed over time, making it ideal for regular maintenance and ongoing longevity protocols. SubQ is also available for home administration through our Home Vitamin Shot Program.

How quickly will I notice the effects of NAD+?

Some clients notice improved mental clarity and energy within a few days of starting a NAD+ protocol. The deeper cellular benefits — improved mitochondrial function, DNA repair support, and anti-aging effects — are cumulative and build over weeks to months of consistent treatment.

Is NAD+ the same as NMN or NR supplements?

NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are precursors to NAD+ — the body converts them into NAD+ after absorption. Injectable NAD+ delivers the molecule directly, bypassing the conversion step. This makes injection a more direct and reliable method of raising cellular NAD+ levels compared to oral precursors.

Can I self-administer NAD+ at home?

Yes — through our Home Vitamin Shot Program. After medical clearance and a 1:1 training session with a registered nurse, qualified clients can self-administer NAD+ SubQ injections at home. The injection is subcutaneous (into a fatty area), uses a very fine needle, and is virtually painless for most people.

Are there any side effects?

NAD+ SubQ is generally well-tolerated. Some clients experience mild injection site discomfort or temporary flushing. The side effect profile is significantly milder than IV NAD+ infusion, which can cause nausea, chest tightness, or flushing during the infusion. SubQ delivery is slower and gentler.

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